Good Evening My wife is a deabetic and hypertensive since last 13 years her creatinine has shooted up to 2.5 per cent and it was 1.5 in last October. She often gets shivering from inside and also now shaking of the body. It was expected that shivering was due to some infection particularly urine infection. But it is not so all the tests done for urine infection is not negative or negligible. She was hospitalised in three of the leading hospitalised thrice for a total period of 18 days all types of anti-biotics like levoflox 750mg and in hospitalisation she was administered meropenem injection 500mg and after discharge meropenem 200 mg was given continuously. In a earlier hospital Roc[; 4.5c 100ml NS amd Donzer 40mg IV and the tablets given are Cilacar20 mg Moxilong 3mg Nebilong Lacix clopitarva Eido Dolo 650 Levobact250mg Arkamin 100mg Lacarnit 330 Cardivas 6.25 Zyntanix 5mg Renalog Renosave Sobosis forte Doxy 1 Minipress 5mg Apresol 25 Maepluylli 100 Livogen Atarva 20mg Dec 100mg Dytor 10mg Dytor Injection Dytor 100mg Stalopam Lonitab. Even after all these medicines and hospitalisation in three leading Hospitals the shivering is not subsiding and since 5 days body shading has started. And now she is on Advent 625 and Dolo twice in a day. Please advise and guide what to do. We family people are much much worried.