I take 200-400 mg of ibuprofen once a day before bed. Even before I started this regimen I would get black/purple bruises all over my legs and hips. Also, my legs get very fatigued. In the past few months the bruising has increased, and I now have the bruising on my arms. I look like a spotted dalmation. Also, they are painful to even the slightest of touches. I also currently take Neurontin and an estradiol patch. Because I had the bruising before I started the ibuprofen, I wasn t sure if that could even be the problem, or if their could be another explanation....?