What Causes Raspy Voice Along With Coughing Up Of Mucus While On PICC Line?

My husband is on a picc line for an infection after a rotator cuff surgery and he is being treated aggressively because of the staph infection possibly into the bone. Now he has had a change in his voice. It has gotten deep and raspy for the past 4 days and his sinuses seem also to be acting and coughing up some mucus which he feels is coming from his sinus. He doesn t feel like a cold and has no other symptoms and doesn t feel sick. I worry that it could be thrush also his tongue looks ok. The other thing is that it could be a cold and it just hasn t developed enough.