Hi Dear, Welcome to HCM. Understanding your concern. As per your query you have restless leg syndrome while on Gabapentin . Well there can be many reasons for symptoms you mention in query like nerve compression , neuropathy , DVT , muscle spasm or multiple Sclerosis , but in your case the symptoms is due to restless leg syndrome which is a neurological disorder. If condition doesn t get well then consult orthopedic surgeon as well as psychiatrist for proper examination. Doctor may prescribe methotrexate , anti inflammatory long with nerve supplement and recommend physical therapy . Along with that doctor may also prescribe antiepileptic drug I would suggest you to do light stretching exercises along with gentle massage , apply warm compresses on entire leg and take muscle relaxants like orthodox MR . Do not sit or stand for long time in one position , do yoga , meditation , avoid alcohol and caffeinated products and keep your legs in hot water tub with Epsom salt for 15 minutes. If condition doesn t get well then consult orthopedic surgeon as well as psychiatrist for proper examination. Hope your concern has been resolved. Get Well Soon. Best Wishes, Dr. Harry Maheshwari