What Causes Restlessness In The Legs While On Ultram And Naltrexone?

Hello. My wife take Ultram each day for pain. She took 4 yesterday. Her doctor has her trying out Naltrexone She broke it up in distilled water and literally only took 1mg last night. She is having a reaction to it.She has severe restless legs (not like I have seen but literally has to keep them flopping around). She says she feels like she s coming down off some strong drugs. She s very unsettled. She takes Ativan sometimes and took one but it s not helped.