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What Causes Rise In GPT Levels In Blood?
GPT from blood test very high // my father who is 75 had a blood test and GPT value is very high 388//gamma-glutamil also high 96.He also had an ultrasound which was ok /liver,kidneys a.s.o.My father takes pills for cholesterol,heart and blood pressure.I wander why GPT is so high as well as the other result gamma-glutamil
Wed, 31 Jan 2018
Hello and Welcome to Healthcare Magic,
There are many things, but my first question is what is the level, if any, of alcohol consumption in this situation? If alcohol is not a culprit there are many other considerations:
* Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present.
*Elevated serum GGT activity can be found in diseases of the liver, biliary system, and pancreas. In this respect, it is similar to alkaline phosphatase (ALP) in detecting disease of the biliary tract.
*More recently, slightly elevated serum GGT has also been found to correlate with cardiovascular diseases and is under active investigation as a cardiovascular risk marker. GGT in fact accumulates in atherosclerotic plaques, suggesting a potential role in pathogenesis of cardiovascular diseases, and circulates in blood in the form of distinct protein aggregates, some of which appear to be related to specific pathologies such as metabolic syndrome, alcohol addiction and chronic liver disease.
This is why it is important to look at liver enzyme ratios and total health history in interpreting this test. Interpreting labs is both an art and a science as is medicine, in general.
I hope I have helped you to understand the indications of this test and the complexities associated with its interpretations with regards to your father.
My best of luck to you,
Kathryn J. Shattler, BS, MS, RDN
https://www.bit.ly/askkathyshattler HealthcareMagic Online Direct Portal
There are many things, but my first question is what is the level, if any, of alcohol consumption in this situation? If alcohol is not a culprit there are many other considerations:
* Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present.
*Elevated serum GGT activity can be found in diseases of the liver, biliary system, and pancreas. In this respect, it is similar to alkaline phosphatase (ALP) in detecting disease of the biliary tract.
*More recently, slightly elevated serum GGT has also been found to correlate with cardiovascular diseases and is under active investigation as a cardiovascular risk marker. GGT in fact accumulates in atherosclerotic plaques, suggesting a potential role in pathogenesis of cardiovascular diseases, and circulates in blood in the form of distinct protein aggregates, some of which appear to be related to specific pathologies such as metabolic syndrome, alcohol addiction and chronic liver disease.
This is why it is important to look at liver enzyme ratios and total health history in interpreting this test. Interpreting labs is both an art and a science as is medicine, in general.
I hope I have helped you to understand the indications of this test and the complexities associated with its interpretations with regards to your father.
My best of luck to you,
Kathryn J. Shattler, BS, MS, RDN
https://www.bit.ly/askkathyshattler HealthcareMagic Online Direct Portal
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