On 25mg single use dose methotrexate subcutaneous. Experienced severe upper thigh leg cramp/dizzy, nauseated, cold sweat tonight earlier episode 1-1: severe pain upper gut with belching, nauseated, dizzy, cold sweat. Physcian ordered Holts monitor for one month/no significant results liver enzymes were elevated after labs following first event stopped methotrexate from 1-9 until tonight liver enzymes were normal on 2nd lab work