This type of medicine is known for causing drowsiness, dizziness, low sex drive, fatigue etc. Major depressive disorder treatment should be supported by pure herbal brain tonics which also correct nervousness and other tiring problems. Brahmi herb is one such herb. To my own patients I would give Brahmi pure herb capsule 1bid and liquid Saraswatarisht and Ashwagandharishta 10 ml each plus equal water after meals. No side effects. No counteraction with anti depressants. Give little gap between both allopathic and Ayurvedic med. May continue for 8 to 16 weeks at a stretch. Then you always have option to stop....but you won t after 4 weeks. You will be immensely benefited. Hope it helps you.