What would cause sporadic sharp bone pain in the legs? The only small relief is when my wife walks a little bit or pounds with her fists, on her thighs...It is excruciating for her and happens several times a day, but mostly at night. She has been receiving treatment injections for RA, for her joints, for about a year now, but this bone pain has been happening for about the last 3 months. The RA dr. does not know what is causing the strong , full bone pain.