Hi, Thanks for asking. I understand your concern. Short breath with chest pain can occur in various conditions like severe anemia/bronchitis or exacerbation of asthma with severe lower respiratory tract infection. But in case of your grand mother with history of severe Mitral valve regurgitation, shortness of breath,chest pain ,swelling in ankles.. point to possibility of - heart muscles problem/ insufficiency in blood supply ( coronary vessel blockage ) , primary stage of heart disease or failure- She needs urgent consultation of her cardiologist , get investigated to pin point the cause & specific management. Till then ..let her - - Take rest, physical & psychological -Sleep in propped up position/ in slanting chair - as per her comfort. - Have heart friendly diet ( vegetable soups/ fruit juices( should not be sour in case of associated cough)/ Dry nuts( almonds, walnuts) in powdered form mixed in cow milk) - Continue with medicines prescribed till her doctor changes them. Thanks