Hello. Thank you for writing to us at healthcaremagic I will keep a possibility of dyshidrotic eczema/pompholyx. Detergents and other irritants like soaps may be an inciting cause in pompholyx. Pompholyx presents as itchy fluid filled blisters/vesicles along the sides of the fingers and toes, palms and soles. The blisters are deep, tense and feel like grains. They can increase in size and become painful, the thick skin of palms and fingers preventing them from rupturing. The lesions of pompholyx can develop as an allergy to metal salts such as nickel, cobalt, chromium. Nickel is usually present in ornaments like bangles, rings etc or is ingested in food. Exposure to other salts may be occupational. Other possible allergens include allergens Or chemicals such as perfumes and irritants such as detergents etc. Those individuals who are allergic have a higher chances of developing pompholyx and it is believed to be a type of allergic reaction. Treatment includes topical application of a potent topical steroid + antibiotic cream twice daily for 2 weeks. An OTC antihistamine e.g cetrizine would help in providing symptomatic relief from itching. I would suggest that you consult a dermatologist. Your treating dermatologist might choose to give you a short course of oral steroids for a week. regards