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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Sudden Gain In Body Weight While On Pamelor?

Hi, I was diagnosed with Fibromyalgia in 2000, so 16 years ago. My neurologist has helped me stay functional with various medications over the years, with more or less success. Recently, she put me on Pamelor (Noritryptiline) 75 mg at bedtime, she said to help curb next-day pain and at the same time took me off Trazodone (which was originally recommended for sleep improvement). I m suddenly gaining weight very quickly, which is (only one) reason I couldn t take Lyrica. Is Pamelor known to cause rapid weight gain? And if so, what would you recommend instead? (looking for 2nd opinion) I am female, 55 and used to be energetic and very slender...thank you. Also wondering about Savella, which I recently heard can be recommended for Fibro, but one I haven t tried yet. Edit: Never mind, thanks. I ve already paid for this service before and didn t get any help.
Mon, 22 Apr 2019
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Internal Medicine Specialist 's  Response
Hello,

Tricyclic antidepressants(TCAs) including nortriptyline frequently cause considerable weight gain. Consider reducing the dose to 50 mg/day.

For patients whose pain is associated with fatigue, anxiety, or depression, drugs that have both analgesic and antidepressant/anxiolytic effects, such as milnacipran (Savella), may be the best first choice.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Tushar Kanti Biswas, Internal Medicine Specialist
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What Causes Sudden Gain In Body Weight While On Pamelor?

Hello, Tricyclic antidepressants(TCAs) including nortriptyline frequently cause considerable weight gain. Consider reducing the dose to 50 mg/day. For patients whose pain is associated with fatigue, anxiety, or depression, drugs that have both analgesic and antidepressant/anxiolytic effects, such as milnacipran (Savella), may be the best first choice. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Tushar Kanti Biswas, Internal Medicine Specialist