My mother is 82 years old and just told me her ankles are swollen and have been since last night. they are not sore or stiff, but noticeably swollen. I ll take her to the doctor monday morning, but should I be concerned now? she is taking the following meds: Eliquis, Metoprolol, Lisinopril, Vesicare, Digoxin, Folic acid, Magnesiun oxide, Cyanolobacamin, Propafenone HCL, and Amlodipine Besylate.