Within the last week each morning when I wake up my left hand is swollen especially around the joint on my index finger. It is so painful I have trouble writing (I m left handed). I also notice I have a little pain in my right hand, but it goes away pretty quickly. The pain and swelling in my left hand gets better during the day but is still a problem when I go to bed (then much worse again in the morning). I recently changed two prescriptions...I went from taking Simvastain to 10 mg Prendastatin (sp?) each night (it s a different cholestohol. I thought this might be the cause so I quit taking the Predestatin for 5-days but symptons didn t change. I also am diabetic and my Dr. precscribed that I take an extra 4 mg of Glimepiride at night in addition to the 4 mg I take during the day. I wonder if this is causing the sudden hand swelling?