My husband was diagnosed with rheumatoid arthritis last Monday and immediately began treatment with methotrexate. He is in his third weed of eating a diet to reduce inflammation (Whole30 - with no processed sugar, no dairy, legumes, grains or anything processed), yet today his hands are swelling again and joint pain has increased also today in his knees and shoulders. I was wondering if this might be a reaction to his new medicine. He takes 4 pills once a week, and tomorrow will be his second dose.