Hi & Welcome to HCM.
I appreciate your concern for your beloved husband's swollen itchy spots on his hands.
Apparently he has developed an
allergic reaction to shrimps while handling handling them.
Allergic reaction to shrimps is unpredictable, sometimes occurring long after a person has handled & eaten the shrimps and has shown no other symptoms.
Allergic reaction to shrimp may also become more severe with each exposure.
So, he must try to avoid direct exposure to the shrimps.
A
dermatologist consultation is recommended to confirm the
allergy to shrimp by certain lab tests like Skin prick test and allergen-specific IgE antibody test or radioallergosorbent (RAST) test.
Meanwhile he can use the following for the relief of his symptoms:
Hydrocortisone 1% cream to be applied to the affected areas twice
Oral Antihistamine (levocetrizine) to reduce as
rash and itchiness.
Hope to have answered your query.