Mild, uncomplicated cases of mesenteric lymphadenitis and those caused by a virus usually go away on their own. Medications used to treat mesenteric lymphadenitis may include: Over-the-counter pain relievers and fever reducers may help relieve discomfort. Use caution when giving aspirin to children or teenagers. Though aspirin is approved for use in children older than age 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin. This is because aspirin has been linked to Reye s syndrome, a rare but potentially life-threatening condition, in such children. Antibiotics may be prescribed for a moderate to severe bacterial infection.