What Causes Tiredness And Appetite Loss After Taking Xtandi For Prostate Cancer?

My name is Elizabeth and i want to ask you for my brotherwho has prostate cancer seventeen years ago and it came back Dec2013 and he has go for chemo for seven times and now his doctor put him on the drug extandi he has been taking it for almost one month but he feel very tired and no appetite and his moood change a lot and he is crying a lot what can I do for him. My bother live in sydney Australia Thank you