Hi and thank you for your reply. I am taking clopidogrel 75 MG, also have stents since 2004, have had a lower bypass of a stent in 2006. also I am on Simvastatin 40 MG for low cholesterol reading as well as high triglyceride readings. up until last month I was taking 75MG Plavix since 2006. also I take 24MG Hydrochlorothiazide for HBP. along with one low dose Bayler 81MG per/day.and last I take fluticasone Propionate Nasal spray 50mcg. I felt wonderful until I started taking Clopidogrel one month ago, in the Simvastatin? I get very tired very fast, have dark yellow urine, a greater amount of muscle pain. ( I have RA but not being treated) and have notice a big change in my vison and a lot of bruising! I never had these problems when I was taking Plavix? EDF is much worse! I am a male at age 63. Also I might mention I have not had lab done in over a year, and never had lab done let on these drugs Simvastatin & Clopidogrel? I have Medicare ins., but it appears they don t allow lab but once a year. Been wanting to see my doctor but having problems getting a appointment set up? So ins. would not pay for Plavix so he called in this Clopidogrel! But no lab in a year, so he has no idea of my problems! Last time I saw him was April, 2013. I welcome your input. Thank you, Robert Stevenson