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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Tiredness, Yellow Colored Urine And Muscle Pain After Taking Clopidogrel?

Hi and thank you for your reply. I am taking clopidogrel 75 MG, also have stents since 2004, have had a lower bypass of a stent in 2006. also I am on Simvastatin 40 MG for low cholesterol reading as well as high triglyceride readings. up until last month I was taking 75MG Plavix since 2006. also I take 24MG Hydrochlorothiazide for HBP. along with one low dose Bayler 81MG per/day.and last I take fluticasone Propionate Nasal spray 50mcg. I felt wonderful until I started taking Clopidogrel one month ago, in the Simvastatin? I get very tired very fast, have dark yellow urine, a greater amount of muscle pain. ( I have RA but not being treated) and have notice a big change in my vison and a lot of bruising! I never had these problems when I was taking Plavix? EDF is much worse! I am a male at age 63. Also I might mention I have not had lab done in over a year, and never had lab done let on these drugs Simvastatin & Clopidogrel? I have Medicare ins., but it appears they don t allow lab but once a year. Been wanting to see my doctor but having problems getting a appointment set up? So ins. would not pay for Plavix so he called in this Clopidogrel! But no lab in a year, so he has no idea of my problems! Last time I saw him was April, 2013. I welcome your input. Thank you, Robert Stevenson
Wed, 12 Dec 2018
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Internal Medicine Specialist 's  Response
Hello,

Your muscle pain, fatigue is due to Simvastatin which can cause Myopathy; rhabdomyolysis, fatigue. To confirm go for serum Creatine phosphokinase level.

You need to lower the dosage of Simvastatin (Adults dosage PO 5 to 40 mg/day in the evening).Clopidogrel/Plavix is not the offending drug.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Tushar Kanti Biswas, Internal Medicine Specialist
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What Causes Tiredness, Yellow Colored Urine And Muscle Pain After Taking Clopidogrel?

Hello, Your muscle pain, fatigue is due to Simvastatin which can cause Myopathy; rhabdomyolysis, fatigue. To confirm go for serum Creatine phosphokinase level. You need to lower the dosage of Simvastatin (Adults dosage PO 5 to 40 mg/day in the evening).Clopidogrel/Plavix is not the offending drug. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Tushar Kanti Biswas, Internal Medicine Specialist