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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Unconjugated Bilirubin Reading To Be Very High?

Hi, my unconjugated bilirubin reading is abnormally high, while the conjugated reading is normal. Besides, all other liver function indicators are normal. I had my gall bladder removed several years ago too. What do think is responsible for this unusual readin. Olayinka
Mon, 13 Jun 2016
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Gastroenterologist,  's  Response
Thank you for posting query.

noted that you have abnormally high uncojugated bilirubin.

increased bilirubin is termed as Jaundice.
Bilirubin is conjugated in the liver.
Bilirubin is derived from the breakdown of heme. Hemoglobin is a complex protein found in Red blood cell that plays important role in transport of oxygen/CO2 from lung to tissues and vice versa.

Increased breakdown of hemoglobin will lead to increased heme production and ultimately increased bilirubin. These abnormally high bilirubin can NOT be conjugated by liver and circulate in blood.
therefore, high uncojugated bilirubin indicates "Hemolytic Anemia" (abnormal (increased)breakdown of red blood cell.)

You need to do following test:
Complete Blood cell count (CBC)
Peripheral Blood Smear

Lab results maybe posted here or visit your treating physician / hematologist/ hepatologist.

my name "Dr Tayyab Malik"

you may find me in gastroenterology panel@HCM.
you may also put a "direct question" to me via this portal or by contacting HCM admin.

any further questions are welcomed.
wish you good and sound health.

regards,
Dr Tayyab Malik
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What Causes Unconjugated Bilirubin Reading To Be Very High?

Thank you for posting query. noted that you have abnormally high uncojugated bilirubin. increased bilirubin is termed as Jaundice. Bilirubin is conjugated in the liver. Bilirubin is derived from the breakdown of heme. Hemoglobin is a complex protein found in Red blood cell that plays important role in transport of oxygen/CO2 from lung to tissues and vice versa. Increased breakdown of hemoglobin will lead to increased heme production and ultimately increased bilirubin. These abnormally high bilirubin can NOT be conjugated by liver and circulate in blood. therefore, high uncojugated bilirubin indicates Hemolytic Anemia (abnormal (increased)breakdown of red blood cell.) You need to do following test: Complete Blood cell count (CBC) Peripheral Blood Smear Lab results maybe posted here or visit your treating physician / hematologist/ hepatologist. my name Dr Tayyab Malik you may find me in gastroenterology panel@HCM. you may also put a direct question to me via this portal or by contacting HCM admin. any further questions are welcomed. wish you good and sound health. regards, Dr Tayyab Malik