Hello! Welcome and thank you for asking on HCM! Regarding your concern, I would ex-plain that prednisone as almost all the other corticosteroids has the potential for sodium and water retention and hence weight increase (in fact is a pseudo-increase, as it is not a real tissue mass increase). The longer the period of corticosteroids therapy, the greater the weight gain effect. But, don t worry about that! If you don t have a decreased cardiac performance (measured by cardiac ultrasound), this effects will be relieved gradually without the need for additional treatment. If you have a previous history of heart failure, you may need to adjust your daily diuretics dose. So, I recommend you to consult with your attending doctor and review your overall clinical status, as I explained above. Hope to have been helpful to you! Greetings! Dr. Iliri