Hi, A small white spot on the shaft of the penis that looks like a zit could be several things. It could be a sebaceous cyst, which is a small, harmless bump that forms under the skin. These cysts are typically painless but can become infected, causing redness, pain, and inflammation. Another possibility is a pimple or folliculitis, which occurs when hair follicles become infected or inflamed. This can cause small white or red bumps to appear on the skin. It s also possible that the spot is a genital wart, although this is less likely if you and your wife have been faithful to each other and she has tested negative for sexually transmitted infections. It s important to have any new or unusual symptoms checked out by a healthcare provider. They can examine the spot and determine the cause, and if necessary, recommend the appropriate treatment. If it is a cyst, pimple, or folliculitis, the spot may go away on its own or require topical treatment. If it is a genital wart, treatment may involve medications, cryotherapy, or surgical removal. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician