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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Could High MPV, Consistently Declining WBC And MCHC Indicate?

Hi I am a 33 year old African American woman. My lab results have consistently read a high mpv for over 5 years. The last 3 years my WBC has been on a consistent decline. Not to severe but slowly decreasing my MCHC is also low just wonder if these have any commonality with one another.
Fri, 2 May 2014
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Pathologist and Microbiologist,  's  Response
Hello and welcome to HCM,
MCV stands for mean corpuscular volume.
MCV is elevated in macrocytic anemia.
Macrocytic anemia is seen in vitamin B12-folic acid deficiency, alcoholism, liver diseases, etc.
However, MCHC is elevated in macrocytic anemias.
In your case the MCHC is decreasing.
The white blood cell count is either unaffected or slightly decreased in megaloblastic anemia.
These findings are not going well with each other.
Kindly, get your hemoglobin to know whether you have anemia or not.
If there is no anemia, (hemoglobin level is normal) the values of MCV and MCHC may be erratic.

Thanks and take care
Dr Shailja P Wahal
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What Could High MPV, Consistently Declining WBC And MCHC Indicate?

Hello and welcome to HCM, MCV stands for mean corpuscular volume. MCV is elevated in macrocytic anemia. Macrocytic anemia is seen in vitamin B12-folic acid deficiency, alcoholism, liver diseases, etc. However, MCHC is elevated in macrocytic anemias. In your case the MCHC is decreasing. The white blood cell count is either unaffected or slightly decreased in megaloblastic anemia. These findings are not going well with each other. Kindly, get your hemoglobin to know whether you have anemia or not. If there is no anemia, (hemoglobin level is normal) the values of MCV and MCHC may be erratic. Thanks and take care Dr Shailja P Wahal