My niece is a 22 year old young woman who suffers from ADHD, and Bi-Polar disorder. She recently broke out in hives and a red rash all over, her face, chest, and back. She was given some Benadryl and an Epi-pen was used on her in the hospital. It worked, but the symptoms returned the next day. Could these be symptoms of Lupus, or could it just be stress related? She has been under a significant amount of stress as of late.