in my opinion , estrogen may not directly related to lumps in calf region ,though we listening many patients complaining lumps in breast after taking estrogen long term. for your calf pain probable causes may be . Varicose veins . You might be familiar with these, because you can see them at the surface of the skin. They appear to be twisted, dark blue or purple veins, and are caused by weak valves and vein walls. They may cause a dull ache, especially after standing. Blood clot. When your blood thickens in a vein and clumps together, it can turn into a clot. One that develops in a vein deep in the body is called deep vein thrombosis (DVT). Tendinitis. One of the first warning signs you have an inflamed Achilles tendon is pain in your lower calf, near the back of your heel. It’s a common injury that makes the tendon swell, stretch, or tear. You can get it from overworking the calf muscle or climbing the stairs. It might stick around for a long time, too note : kindly visit surgeon in nearst govt hospital , you definitely treated well. I hope you happy with information, kindly rate it. thank you.