Sir, I m Tamanna Sultana from Bangladesh.My age is 27. Our marriage life is almost 6 years.In the min time, we have 2 blighted ovum history. First one was January, 2013 and second one was November,2015.After my second miscarriage, my gynecologist did certain tests and is was found that my TSH level was high (12 uIU/ml) and prescribed me levothyroxine sodium 50mcg (1 and 1/2) daily. She suspected that this is the cause of my multiple blighted ovum. So she referred me to an endocrinologist. After one week later, my endocrinologist did some tests, which results were mentioned below: Anti-Thyroid Antibody: Test Result Reference Value Anti- Thyro Globulin Ab (Anti-TG) 1400 IU/ml 5-100 IU/ml Anti- Thyroid Peroxidase Ab (Anti-TPO) 500 IU/ml 1-16 IU/ml Test Result Reference Value TSH 0.24 uIU/ml 0.04-4.0 uIU/ml Free T4 2.35 ng/dl 0.80-1.90 ng/dl So this time,my TSH level was below the normal range and antibody’s level was too high.So my endocrinologist reduce the doses of medicine, (1+0+0) daily, levothyroxine sodium 50mcg. After two months I did the tests again and result was Test Result Reference Value TSH 45.0 uIU/ml 0.04-4.0 uIU/ml Free T4 0.82 ng/dl 0.80-1.90 ng/dl And this report was rejected by my doctor because according to TSH level,T4 should be below the range but is was normal. But he increased the doses of medicine, (3+0+0 in fri-sat and 2+0+0 in sun-Thursday).After 6 weeks later, I did the test again and result was Test Result Reference Value TSH 0.17 uIU/ml 0.04-4.0 uIU/ml Free T4 20.33 pmol/L 11.5-22.7 pmol/L Again, TSH level decreased and my dr. Reduces the doses (2+0+0) every day. And after 2 months now my TSH Level is Test Result Reference Value TSH 10.08 uIU/ml 0.04-4.0 uIU/ml Free T4 15.62 pmol/L 11.5-22.7 pmol/L Free T3 3.35 pg/ml 2.77-5.27pg/ml And ESR level is high, which is 26 mm in 1St hour. So this is the total history of last 7 months and I’m so depressed because my TSH level is still not in controlled. And I’m eagerly waiting for a baby. But my previous BO history does not allow me to be pregnant again. Now my endocrinologist suggests me to try for a baby again and beside this he told me to do some genetic test .As blighted ovum is a result of defective chromosomes or abnormal cell divisions. I really don’t know what I should do. I badly need your advice. Please help me. I hope, you can understand my situations. If you think, I should do more tests,please kindly suggest me. Thanks. Tamanna Sultana