Hi, The results of your thyroid antibody test show that you have elevated levels of both TGB and TPO antibodies, which indicates that you have an autoimmune thyroid disorder such as Hashimoto s thyroiditis. Hashimoto s thyroiditis is a condition where your immune system mistakenly attacks your thyroid gland, leading to inflammation and damage to the thyroid tissue. The elevated levels of TGB antibodies (730.2, where the reference range is 0.0 - 0.9) suggest that your immune system is specifically targeting thyroglobulin, a protein produced by the thyroid gland that is essential for the production of thyroid hormones. The elevated TPO antibodies (47, where the reference range is 0 - 34) indicate that your immune system is also attacking an enzyme called thyroid peroxidase, which is involved in the production of thyroid hormones. These antibodies can interfere with the thyroid gland s ability to produce thyroid hormones, leading to hypothyroidism, which is likely the reason why you were diagnosed with hypothyroidism approximately 5 years ago. The medication you are currently taking (Armour thyroid) is a hormone replacement therapy that is used to supplement your thyroid hormone levels. The elevated TGB antibodies are not necessarily suspicious of thyroid cancer. However, it is important to follow up with your healthcare provider to discuss your test results and any concerns you may have about your thyroid health. Your healthcare provider may recommend further testing, such as a thyroid ultrasound or a biopsy if there are any concerns about the possibility of thyroid cancer or other thyroid disorders. In addition to the thyroid antibody test results, your thyroid hormone levels are also important to consider. Your TSH level (2.060, where the reference range is 0.450 - 4.500 uIU/mL) is within the normal range, indicating that your thyroid hormone levels are currently well-managed with your medication. However, your Free Thyroxine Index (1.0, where the reference range is 1.2 - 4.9) and Thyroxine (T4) Free, Direct (0.76 ng/dL, where the reference range is 0.82 - 1.77) levels are lower than the normal range, indicating that your medication may need to be adjusted to ensure optimal thyroid hormone levels. Your healthcare provider can guide you on the appropriate next steps based on your test results and medical history. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician