Hi, Thanks for posting your query in health care magic. I understand your concern. Empty nest syndrome is not a clinicial condition as such, but it is just the feeling of grief and loneliness due to the sudden absence of child. So the feeling of grief and crying over your granddaughter definitely implies that, you have empty nest syndrome or it could be Depression . I suggest you to consult a psychiatrist and get help to get over your painful emotions by prescribing you mood elevators. The thought of meeting your grand daughter only in the weekend could itself cause you more grief, so its better you to keep yourself occupied with hobbies like reading books, gardening, cooking and watching good entertainment programs. Hope this answers your query satisfactorily. Do feel free to write back to me for further assistance. Wishing you feel better soon. Take care