Hello my husband has glioblastoma grade 4 two year ago we went to the following procedures,surgery of the tumor in the frontal lobe, radiation and temodar for 2months, then 5days cycle monthly also on temodar , six months later he had a progression of the tumor , we stopped temodar and started on avastin every two weeks, he did well until two months ago he had a recurrent again, so we gave him one cycle of avastin and camptozar combination, his motor function is getting worse, what should I expect now?