What is the best medicine for vagina itching and dryness. I have MS and diabetic. I only itch when I wipe, the itching is so bad at times, I try not to scratch but do rub the area immensely to the point I almost have an orgasm. My Dr. said no yeast infection put me on vagnisil cream but only helps a little. Could the fentanyl patch cause the itching? I no longer wear it, was causing an overdose of the medicine receiving too much at one time, the last three times I wore the patch.