What is the symptoms of too much Niacin 500mg non flushing? I take 1 cap twice daily for high Cholesterol since I cannot tolerate statins. For 3 weeks I have very sore ligaments, tendons, muscles and joints. I feel like my liver and kidneys are not functioning efficiently at removing the by products of any exercise. I am female and 72 and have osteoarthritis, heart disease, degenerative disc disease, hypertension, high cholesterol, level 4 kidney failure from long term use of NSAIDS. My last 3 check ups at my Kidney Clinic were excellent with no more symptoms in a two year period since I stopped taking NSAIDS. I can give you my medication list if you request this.