Hello and welcome, Most research on mast cell disorders are on mastocytosis (proliferation of mast cells, sometimes regarded as a neoplasm) rather than mast cell activation syndrome/disorder. Not as much is known about mast cell activation syndrome - it is really a rather new disorder and it isn t fully established how to diagnose it or what various health problems it is definitely linked to. However, as you probably know, the symptoms of mast cell activation syndrome are treated essentially the same as mastocytosis, with the medications that your listed. I cannot find definitive data about the effects of surgery on mast cell activation syndrome. Various stresses can trigger symptoms of systemic mastocytosis, and surgery is certainly a physical stressor. While I am neither an allergist nor immunologist, in thinking on this I would not assume that mcas is an absolute contraindication if you are monitored carefully during surgery and the procedure is done in a setting where the possibility of anaphylaxis or other severe reactions can be addressed immediately. One thing that you could consider is requesting that an anesthesiologist monitor your surgery (rather than a nurse anesthetist) and perhaps you can make an appointment for a consult with the anesthesiologist ahead of time to explain your complicated situation. Other than immunologists and allergists, there is not much awareness of this disorder and you may need to help explain your problem and needs. Is the physician who is prescribing the mast cell stabilizer and anti inflammatory mediator meds (H1, H2, Leukotriene - blockers) well informed about your situation? If so, you can consider asking him/her to send a letter to the anesthesiologist explaining your medical history and needs prior to your meeting with or talking with the anesthesiologist. One other thing: If you were on a corticosteroid, that would be a problem for surgery. But you didn t list any steroids, so I am assuming you aren t on any. I hope this helps. I wish there were more solid research on mast cell activation syndrome. I am glad you found a practitioner who has helped you with the medications that your are now on. Good luck to you.