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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Which Is The Best Treatment For Mast Cell Tumor?

What treatment is suggested for a mast cell tumor that was a grade 2 mitotic index 9? The tumor was on his back leg and they were unable to get better margins because of location. Would you recommend radiation, chemo, palladia, or just let it heal? I have a 10 yr old chocolate lab. Just wondering statistical outcomes on each treatment.
Thanks for your information.
Tue, 7 Apr 2015
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Pulmonologist,  's  Response
Thanks for your question on HCM.
I can understand your situation and problem.
Mast cell tumour is aggressive skin tumour.
Without treatment it will surely worsen.
The best treatment is enblock surgical removal of involved skin.
Since you have irresectable margins, we can try preoperative radiotherapy and chemotherapy to decrease the size of tumour.
By doing this, we can achieve good margins and thus surgery can be possible.
With enblock surgery, life expectancy is almost 3-4 years. Five year survival rate is 50-60%.
So better to first go for chemotherapy and radiotherapy to decrease the size of tumour and then go for enblock surgery for better outcome.
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Which Is The Best Treatment For Mast Cell Tumor?

Thanks for your question on HCM. I can understand your situation and problem. Mast cell tumour is aggressive skin tumour. Without treatment it will surely worsen. The best treatment is enblock surgical removal of involved skin. Since you have irresectable margins, we can try preoperative radiotherapy and chemotherapy to decrease the size of tumour. By doing this, we can achieve good margins and thus surgery can be possible. With enblock surgery, life expectancy is almost 3-4 years. Five year survival rate is 50-60%. So better to first go for chemotherapy and radiotherapy to decrease the size of tumour and then go for enblock surgery for better outcome.