What time of day should I take Amlodipine 5 mg? I am also taking Losartan/HCTZ 100-25 mg in the morning, and Carvedilol 3.125 mg twice a day, morning and night. My doctor recently prescribed this as my blood pressure is high, even with the medicine I was already taken. He didn t tell me what time of day to take it, just once a day. The information I received with the medication doesn t say either. I ve been taking it mid-day. My blood pressure is still high 145-150/90-100. Yeah, I don t think so. I thought this would be free. I can call my doctor and get an answer for free on Monday.