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Which Beta Blocker Gives The Lowest Incidence Of GI Symptoms?
After trialing every class of blood pressure medications, metoprolol worked well for my blood pressure. Unfortunately, my stomach just couldn t handle it. Which beta blocker has the lowest incidence of GI symptoms as well as the lowest incidence of impotence. Thank you.
Mon, 5 Dec 2016
hello and thank you for your question. pleased to answer you
Mechanism of action and classification of beta-blockers (BBL) are different and depends on their capabilities of having receptor selectivities and vasodilating properties, Intrinsic sympathomimetic activities (ISA) and metabolism actions. Then it might be clear that they will have different adverse events depending on their classifications. But, are beta-blockers as effective as other classes of antihypertensive agents?
A 2008 Cochrane review, with betablockers studied in reviewed articles, concluded that the antihypertensive potency of BBL is superior to placebo (a drug without any action on hypertension) but inferior to diuretics, calcium channel blockers (CCB) and inhibitors of the renin-angiotensin-aldosterone system (RAAS).
There was no survival benefit compared to placebo from using BBL in hypertension. Incidence of stroke was higher with the BBL studied than other antihypertensive agents, probably due to lesser blood pressure reduction.
As you have side effects from BBL, I think that you have to change the BBL as hypertensive agents to another family, mostly for side effects and also because BBL are inferior to diuretics, calcium channel blockers (CCB) and inhibitors of the renin-angiotensin-aldosterone system, to treat hypertension and above all to prevent you in the long term from Stroke.
best wishes
Mechanism of action and classification of beta-blockers (BBL) are different and depends on their capabilities of having receptor selectivities and vasodilating properties, Intrinsic sympathomimetic activities (ISA) and metabolism actions. Then it might be clear that they will have different adverse events depending on their classifications. But, are beta-blockers as effective as other classes of antihypertensive agents?
A 2008 Cochrane review, with betablockers studied in reviewed articles, concluded that the antihypertensive potency of BBL is superior to placebo (a drug without any action on hypertension) but inferior to diuretics, calcium channel blockers (CCB) and inhibitors of the renin-angiotensin-aldosterone system (RAAS).
There was no survival benefit compared to placebo from using BBL in hypertension. Incidence of stroke was higher with the BBL studied than other antihypertensive agents, probably due to lesser blood pressure reduction.
As you have side effects from BBL, I think that you have to change the BBL as hypertensive agents to another family, mostly for side effects and also because BBL are inferior to diuretics, calcium channel blockers (CCB) and inhibitors of the renin-angiotensin-aldosterone system, to treat hypertension and above all to prevent you in the long term from Stroke.
best wishes
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