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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Does Different Labs Show Different Results?

Hi. I have my pre medical exam all test are negative except with my vdrl QUALITATIVE is positive and tpha is positive. So the doctor ask my history. And i dont have history of syphilis before and i dont ungergo any treatment so i re tested but now its a VDRL QUANTITATIVE in another laboratory. After 2 days i got the result and it is negative. Its not clear to me what does it mean? I dont have peace of mind.. Please help me..
Wed, 23 Jul 2014
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HIV AIDS Specialist,  's  Response
Hi,
Welcome to HCM.
There are different types of tests available to detect and confirm Syphilis. Some are specific test and confirmatory whereas some are non specific and has prognostic value. In many countries VDRL test became obsolete. In this place they perform Rapid Plasma reaction test. VDRL or RPR remain negative in early disease, prezone or prozone phenomena, technical error, following adequate treatment, substandard equipment, incompetent technician,errors in expressing the results, improper labeling , lysis of specimen etc. TPHA once positive remain positive for ever even after adequate treatment.
Dr S.murugan
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Why Does Different Labs Show Different Results?

Hi, Welcome to HCM. There are different types of tests available to detect and confirm Syphilis. Some are specific test and confirmatory whereas some are non specific and has prognostic value. In many countries VDRL test became obsolete. In this place they perform Rapid Plasma reaction test. VDRL or RPR remain negative in early disease, prezone or prozone phenomena, technical error, following adequate treatment, substandard equipment, incompetent technician,errors in expressing the results, improper labeling , lysis of specimen etc. TPHA once positive remain positive for ever even after adequate treatment. Dr S.murugan