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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Will Anti-nuclear Antibody Detect Dormant Syphilis?

About 10 years ago I had a chancre in my genital area which went away on its own, about a year later I was sick for a week with high fever, I lost weight and had rash in my hands now after 10 years I think I have a syphilis infection left untreated I had an RPR that came back non reactive and I am now waiting on the results of a second test called Anti-nuclear antibody, my question is will this test detect dormant syphilis?
Sat, 15 Feb 2014
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Infectious Diseases Specialist 's  Response
Hi,

Welcome to HCM.

Antinuclear antibodies are abnormal antibodies present which have the ability to bind to certain structures within the nucleus of body cells. These antibodies are more common in autoimmune disorders like SLE, Rheumatoid arthritis, Graves disease and Hashimotos Thyroiditis. These antibodies do not detect dormant syphilis.
RPR is a screening test which detects reagin antibodies seen in syphilis. These tests have to be confirmed by specific tests like TPHA, ELISA and Fluorescent treponemal antibody test.
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Will Anti-nuclear Antibody Detect Dormant Syphilis?

Hi, Welcome to HCM. Antinuclear antibodies are abnormal antibodies present which have the ability to bind to certain structures within the nucleus of body cells. These antibodies are more common in autoimmune disorders like SLE, Rheumatoid arthritis, Graves disease and Hashimotos Thyroiditis. These antibodies do not detect dormant syphilis. RPR is a screening test which detects reagin antibodies seen in syphilis. These tests have to be confirmed by specific tests like TPHA, ELISA and Fluorescent treponemal antibody test. Thanks.