Yes I am taking prempro0.45mg/1.5 mg. I am 51 years old .I smoke- about 3-4 cigarettes a day. I have had anxiety/panic attacks and am on toffranil 100 mg activan 1 mg 2 at night amitriptyline10 mg at night. since menopause I have trouble sleeping . I have always had chest pain /tightness when under a lot of stress. It is usually on the right side under my breast and moves up to my chest on the right side. For about the past 5 mo. it is more frequent and last longer. I did just buy a house moved inJuly,had Christmas ect. And work in a very stressful environment. Had EKG Thursday- normal had x ray of lungs clear. So now I am scheduled for ultrasound of gallbladder,aorta and pancreaus. whats your opinion?