Hi, welcome to our site. I am Dr Saumya Mittal. I am a diabetologist Read your query. That is a very significant question and i appreciate your problem. I will try my best to answer your query What usually happens is that the pancreas, the organ which secrete insulin gradually fails. and therefore the insulin produced is either not enough, or not effective enough. Therefore the sugars reduce because the insulin in the body is effectively less. Since your medicine remained the same while your insulin reduced, the sugars rise again as for kidney functions, just creatinine is not enough. you need to calculate your eGFR. now since I dont have the required details, i will give you a link where you can just put in the detalls and the site will calculate the GFR on its own and tell you. If it is low, you may be developing renal failure, despite having normal creatinine use the following link http://nephron.com/cgi-bin/CGSI.cgi I hope this helps you. Inform the reports mentioned above so i can be of help further. Best of luck. I have given you the answer to the maximum considering the information provided. The results of the tests could further enhance my answer to you. Please do understand that some details could be extracted from a detailed history and examination. Looking forward to your return query with the details asked so that I can help you further. (If the answer has helped you, please indicate this)