i have been on losartan hct 100-25, atovastatin 20 mg, and glimipirde 4mg for several years, but just switched from trulicity to januvia 100mg within the past 6 weeks. I have never before had a problem with leg swelling, but for the past 3-4 week my ankles are swilling and the swelling is now up to my thighs. could the strength of the januvia be causing this. I was on metformin for three or four years at the 50/1000 strength with no leg problems.