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Am I Free From Rabies Infection Inspite Of Having Pre Exposure Prophylaxis?
Question: Is it possible to eradicate virus if present in body before it show any sypmtoms by taking vaccine!!as I have taken post exposure vaccines of rabies 0 3 7 doses and my pet dog is healthy even after 90 days so these will act as pre exposure as dog is non rabid!! So I wAnt to know for how long immunity will remain in my body before any next exposure and if if if any virus present in my body will these 3 doses neutralised it?
Brief Answer:
Rabies vaccination
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
A rabid dog dies within 7 days of developing symptoms. Your pet dog is not rabid. You have taken 3 doses of rabies vaccine (on days 0,3,and 7 ). This will serve as pre-exposure prophylaxis.
There are rare reports, from XXXXXXX Ethiopia, and elsewhere, of chronic excretion of virus in the saliva of apparently healthy dogs.
When a previously immunized individual is exposed to rabies, two booster doses of vaccine should be administered on days 0 and 3.No rabies deaths have been reported in anyone who had pre-exposure vaccine followed by
postexposure booster doses.
The antibody response is so predictable that it need not normally be checked, unless there is immunosuppression. An antibody level above 0.5 IU/ml indicates immunity.
Neutralizing antibody in serum may be detectable as early as 7 days after the start of primary immunization.
If you have doubt ,you can go for serum neutralizing antibody titre against rabies.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Rabies vaccination
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
A rabid dog dies within 7 days of developing symptoms. Your pet dog is not rabid. You have taken 3 doses of rabies vaccine (on days 0,3,and 7 ). This will serve as pre-exposure prophylaxis.
There are rare reports, from XXXXXXX Ethiopia, and elsewhere, of chronic excretion of virus in the saliva of apparently healthy dogs.
When a previously immunized individual is exposed to rabies, two booster doses of vaccine should be administered on days 0 and 3.No rabies deaths have been reported in anyone who had pre-exposure vaccine followed by
postexposure booster doses.
The antibody response is so predictable that it need not normally be checked, unless there is immunosuppression. An antibody level above 0.5 IU/ml indicates immunity.
Neutralizing antibody in serum may be detectable as early as 7 days after the start of primary immunization.
If you have doubt ,you can go for serum neutralizing antibody titre against rabies.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Sir rabies is only transmitted when saliva come in contact with blood or there is any other way also!!and for how many months or years these three vaccine which act as pre exposure RVnab antibody remain in body before any exposure?and sir if dog touch your skin with his mouth for how much time virus remain active in air??
Brief Answer:
Rabies virus transmission
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Rabies Virus can penetrate broken skin and intact mucosa. Humans are usually infected when virus-laden saliva is inoculated through the skin by the bite of a rabid dog or other mammal . Saliva from a rabid animal can infect if the skin is already broken, by the animal's claws for example.
Transmission from non-bite exposures is relatively uncommon.
Aerosols generated in the laboratory or in caves containing millions
of Brazilian free-tail bats have rarely caused human rabies.
Transmission has resulted from corneal transplantation and also
from solid organ transplantation and a vascular conduit (for a liver
transplant) from undiagnosed donors with rabies . Human-to-human transmission is extremely rare, although hypothetical concern about transmission to health care workers has prompted the implementation of barrier techniques to prevent exposures.
Pre-exposure prophylaxis produces neutralizing antibody. People engaged in high risk profession e.g animal handlers should undergo periodic say every 06 months for serum neutralizing antibody titre against rabies. An antibody level above 0.5 IU/ml indicates immunity,Booster dose has to be taken if the titre falls below 0.5 IU/ml .
How long the antibody will remain in body in protective titre varies from individual to individual depending on his immuno-competent state.
However when a previously immunized individual is exposed to rabies, two booster doses of vaccine should be administered on days 0 and 3. One need not undergo serum neutralizing antibody titre .
The rabies virus is readily inactivated by ultraviolet light, drying, boiling, soap solution, detergents,etc.
Virus can survive for sometime in aerosols as evident from transmission of rabies from bat to bat or bat to human beings.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
.
Rabies virus transmission
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Rabies Virus can penetrate broken skin and intact mucosa. Humans are usually infected when virus-laden saliva is inoculated through the skin by the bite of a rabid dog or other mammal . Saliva from a rabid animal can infect if the skin is already broken, by the animal's claws for example.
Transmission from non-bite exposures is relatively uncommon.
Aerosols generated in the laboratory or in caves containing millions
of Brazilian free-tail bats have rarely caused human rabies.
Transmission has resulted from corneal transplantation and also
from solid organ transplantation and a vascular conduit (for a liver
transplant) from undiagnosed donors with rabies . Human-to-human transmission is extremely rare, although hypothetical concern about transmission to health care workers has prompted the implementation of barrier techniques to prevent exposures.
Pre-exposure prophylaxis produces neutralizing antibody. People engaged in high risk profession e.g animal handlers should undergo periodic say every 06 months for serum neutralizing antibody titre against rabies. An antibody level above 0.5 IU/ml indicates immunity,Booster dose has to be taken if the titre falls below 0.5 IU/ml .
How long the antibody will remain in body in protective titre varies from individual to individual depending on his immuno-competent state.
However when a previously immunized individual is exposed to rabies, two booster doses of vaccine should be administered on days 0 and 3. One need not undergo serum neutralizing antibody titre .
The rabies virus is readily inactivated by ultraviolet light, drying, boiling, soap solution, detergents,etc.
Virus can survive for sometime in aerosols as evident from transmission of rabies from bat to bat or bat to human beings.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thanks u sir for ur well detailed answer I really appreciate u!!wants to know only one thing if sumone playing with dog unknown of the status of dog and dog licks his intact skin after that he serves the food to normal people without washing his hand then can rabies spread??and apart from saliva is urine and faeces can also transmit rabies!!
So sir it's necessary that mammal can only transmit rabies if saliva came in direct contact of blood?
And sir how contamination of mucous membrane spread rabies??possible way of it?
So sir it's necessary that mammal can only transmit rabies if saliva came in direct contact of blood?
And sir how contamination of mucous membrane spread rabies??possible way of it?
Brief Answer:
Rabies virus transmission
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Saliva from an infected animal can transmit rabies if the saliva comes into contact with the mouth, nose, or eyes.
Virus cannot penetrate intact skin.
Someone playing with dog (rabid or healthy) will not transmit rabies virus by serving food to others,as rabies virus is not transmitted by fomite (objects).
Rabies virus is excreted through saliva and not by urine or faeces of dog.
From the point of entry, the virus is neurotropic.
Virus can penetrate broken skin and intact mucosa.
Animals can be infected through the gastrointestinal tract, but there is no evidence that this happens in humans.
The transmission of rabies from mother to suckling infant via the breast milk has been suspected in at least one human case and is well known in animals.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Rabies virus transmission
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Saliva from an infected animal can transmit rabies if the saliva comes into contact with the mouth, nose, or eyes.
Virus cannot penetrate intact skin.
Someone playing with dog (rabid or healthy) will not transmit rabies virus by serving food to others,as rabies virus is not transmitted by fomite (objects).
Rabies virus is excreted through saliva and not by urine or faeces of dog.
From the point of entry, the virus is neurotropic.
Virus can penetrate broken skin and intact mucosa.
Animals can be infected through the gastrointestinal tract, but there is no evidence that this happens in humans.
The transmission of rabies from mother to suckling infant via the breast milk has been suspected in at least one human case and is well known in animals.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Prasad
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