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Can Levetiracetam, Furosemide, Cyclobenzaprine And Lamotrigine Be Taken Together?
Question: I am a personal care attendant in XXXXXXX and assist clients with Rx, In California all the Rx's had a "do not take with" type of clause on the pamplet with each medication. One of my clients is usually taking 7 pills daily "Neurology" and she is usually moody, can I be of help?
Levetiracetam 500mg
Furosemide 40mg
Cyclobenzaprine 10mg
Lamotrigine 100mg
Vilazodone 20mg
Nebivolol 10mg
Azilsaratan/Chlorthalidone 40-25mg
Tramadol 50mg
This looks like a cross word puzzle, Is there anything I should know or help with?
Levetiracetam 500mg
Furosemide 40mg
Cyclobenzaprine 10mg
Lamotrigine 100mg
Vilazodone 20mg
Nebivolol 10mg
Azilsaratan/Chlorthalidone 40-25mg
Tramadol 50mg
This looks like a cross word puzzle, Is there anything I should know or help with?
Brief Answer:
Great question, will try to help!
Detailed Answer:
First, all of these can interact with known individual factors (most are eliminated by the liver so there is some increase in the levels accumulated just with aging and a LOT of accumulation with liver disease and some interaction between all of them because they share elimination pathways.... the liver interactions between them is in general Not Too Much).
Chlorthaladone and Lasix are both diuretics and can lower (possibly DRASTICALLY) electrolytes magnesium and potassium. A simple blood test to monitor it 2-3 times a year... if not abnormal and mostly they are NOT abnormal, then that isn't a problem.
Nebivolol and 'sartans are blood pressure medicines. If the blood pressure is good, then they are working. The 'sartans tend to prevent potassium loss from the diuretics. The interactions are generally good. These are very very commonly used together in combination. and are just pretty safe. Furthermore, the problems if they occur in the first week you are on them, or they do not happen.
Oddly enough, they've looked at levetiracetram and blood pressure medicine interaction a great deal, but find no significant issues/interactions/etc.
Then... theres vilazodone, tramadol and maybe flexeril... they interact. Chemically, certainly both vilazodone and tramadol increase serotonin effects in the body and brain. They can cause SEROTONIN syndrome (confusion, diarrhea, flushing) but mostly won't. This condition lasts while the drugs are present ang goes away when the drugs aren't there (about 1 day... worst case). Flexeril, vilazodone, and tramadol ALL and all the anti-epileptic drugs ALL can cause sedation, confusion, disorientation. This effect often increases with more drugs together that cause sedation. Sometimes in very manic upset patients we like this to occur. Mostly, the sedation is a problem.
That's all the commonly occurring issues with the medications. Of course, atypical and allergic responses can occur with any of them in an unpredictable way.
Great question, will try to help!
Detailed Answer:
First, all of these can interact with known individual factors (most are eliminated by the liver so there is some increase in the levels accumulated just with aging and a LOT of accumulation with liver disease and some interaction between all of them because they share elimination pathways.... the liver interactions between them is in general Not Too Much).
Chlorthaladone and Lasix are both diuretics and can lower (possibly DRASTICALLY) electrolytes magnesium and potassium. A simple blood test to monitor it 2-3 times a year... if not abnormal and mostly they are NOT abnormal, then that isn't a problem.
Nebivolol and 'sartans are blood pressure medicines. If the blood pressure is good, then they are working. The 'sartans tend to prevent potassium loss from the diuretics. The interactions are generally good. These are very very commonly used together in combination. and are just pretty safe. Furthermore, the problems if they occur in the first week you are on them, or they do not happen.
Oddly enough, they've looked at levetiracetram and blood pressure medicine interaction a great deal, but find no significant issues/interactions/etc.
Then... theres vilazodone, tramadol and maybe flexeril... they interact. Chemically, certainly both vilazodone and tramadol increase serotonin effects in the body and brain. They can cause SEROTONIN syndrome (confusion, diarrhea, flushing) but mostly won't. This condition lasts while the drugs are present ang goes away when the drugs aren't there (about 1 day... worst case). Flexeril, vilazodone, and tramadol ALL and all the anti-epileptic drugs ALL can cause sedation, confusion, disorientation. This effect often increases with more drugs together that cause sedation. Sometimes in very manic upset patients we like this to occur. Mostly, the sedation is a problem.
That's all the commonly occurring issues with the medications. Of course, atypical and allergic responses can occur with any of them in an unpredictable way.
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Above answer was peer-reviewed by :
Dr. Bhagyalaxmi Nalaparaju
Answered by
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