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Can S-adenosyl Methionine-E Cause High BP?

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Posted on Wed, 28 Dec 2016
Question: I had minor knee surgery about 1 and a half years ago and Sam-E helped a lot. Lately my blood pressure, which is usually normal (120/80) or slightly higher, has been more like 140 to 150 over 85. I stopped taking Ibuprofen for the same reason. Might XXXXXXX E be the culprit? I do tend to be active and athletic and plan to stay that way.
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Answered by Dr. Vaishalee Punj (31 minutes later)
Brief Answer:
Yes it can

Detailed Answer:
Hi
Thanks for posting your query on HealthcareMagic.

I am Dr Vaishalee, MD Pharmacology and will try to help you as best as I can.

SAM-E is S-adenosyl methionine-E. Theoretically it can cause higher levels of serotonin. If taken with Monoamineoxidase-inhibitors or selective serotonin receptors inhibitors, it can potentially cause serotonin syndrome. In both cases, hypertension can happen.

I have tried to find studies on this topic. I could not find any study confirming this. Most studies state that it is safe. I think more and larger studies should be undertaken to look for its side effects.

My opinion is that it should be avoided in hypertension. If its being given with antidepressants, extra precaution should be taken.

Hope it helps.
Let me know if I can assist you further.

Dr Vaishalee
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Vaishalee Punj (13 hours later)
Thank you. That is very helpful.
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Answered by Dr. Vaishalee Punj (5 hours later)
Brief Answer:
Thanks

Detailed Answer:
Thanks

Dr Vaishalee
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Vaishalee Punj

General & Family Physician

Practicing since :2003

Answered : 3266 Questions

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Can S-adenosyl Methionine-E Cause High BP?

Brief Answer: Yes it can Detailed Answer: Hi Thanks for posting your query on HealthcareMagic. I am Dr Vaishalee, MD Pharmacology and will try to help you as best as I can. SAM-E is S-adenosyl methionine-E. Theoretically it can cause higher levels of serotonin. If taken with Monoamineoxidase-inhibitors or selective serotonin receptors inhibitors, it can potentially cause serotonin syndrome. In both cases, hypertension can happen. I have tried to find studies on this topic. I could not find any study confirming this. Most studies state that it is safe. I think more and larger studies should be undertaken to look for its side effects. My opinion is that it should be avoided in hypertension. If its being given with antidepressants, extra precaution should be taken. Hope it helps. Let me know if I can assist you further. Dr Vaishalee