Question: Hello, I have 3 inter-related questions. Background:
I believe I will be taking a serum immunofixation test in the near future to investigate a possible monoclonal protein disease, but I have been vaccinated against rabies several times (I've had unbelievably bad luck accidentally having encounters with bats), most recently in December 2015 and I'm wondering if the vaccination could potentially obscure the results and point toward a plasma cell disease even if one isn't present. My questions are as follows:

1) Would a serum immunofixation test be able to distinguish between a monoclonal protein disorder (multiple myeloma, waldenstrom macroglobulinemia, monoclonal gammopathy of undetermined significance) and globulin abnormalities stemming from hyperimmunization?

2) Would hyperimmunization show a monocolonal or polyclonal pattern on this test?

3) Finally, would having an overall normal globulin level of 2.3g/dl (reference range: 1.5 to 4.5) decrease suspicion of a monoclonal disorder at all? Total protein is 7.4 (range: 6.0-8.5), albumin is 5.1 (range: 3.5-5.5). A/G ratio is 2.2 (range: 1.1-2.5).

Thank you!

Thank you Dr. Puri for explaining that the vaccine will not cause a 'false positive' for monoclonal proteins.

I do realize that my total protein, albumin, globulin, and a/g ratio are all within normal limits, but my understanding is that one can have a monoclonal protein condition with these values being normal. What I'm trying to figure out is whether or not these being normal would greatly reduce the likelihood of a monoclonal disorder, although obviously falling short of actually ruling them out?

Thank you!