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Can Prolonged Intake Of Doxycycline Cause Edema In Feet And Ankles?

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Posted on Thu, 6 Oct 2016
Question: can prolonged use of doxycycline hyclate dr 150 mg (3 months) cause edema in the feet and ankles also a feeling of water droplets falling which are actually inside the body


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Answered by Dr. Vasudha (5 hours later)
Brief Answer:
Consult a physician to exclude serious causes of edema

Detailed Answer:
Hi XXXX,
Thanks for the query. I have read it & understood your concern.
Yes, Doxycycline hyclate is known to cause edema over feet & ankles .. after prolonged use. The feeling of water droplets falling is due to pressure on periferal nerves supplying the skin of the part( periferal nuropathy. )
I don't know how many days have passed after stopping the doxycycline... mostly, if the edema is just a side effect of the drug.. it should disappear in 10 to 15 days ... with normal activities & sufficient water intake .
* But if the edema persists for a longer time one should be aware of
- kidney involvement / aggravation of kidney problem which may be already existing , In this context I would advise for checking urine ( routine & microscopic) & further evaluation & treatment as per need.Please consult your family doctor.

- Health check up for other possible causes of edema feet like joint involvements/ high blood pressure/ weight gain because of diabetes or thyroid problem/ liver problem need to be investigated for as per need, after primary physical examination by a physician.

In short persistent edema feet should be investigated to exclude any concerning cause & treated in time .
I hope, the answer was both informative & useful to you. Any follow up query is welcome,
Thank you.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Vasudha

General & Family Physician

Practicing since :1970

Answered : 10388 Questions

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Can Prolonged Intake Of Doxycycline Cause Edema In Feet And Ankles?

Brief Answer: Consult a physician to exclude serious causes of edema Detailed Answer: Hi XXXX, Thanks for the query. I have read it & understood your concern. Yes, Doxycycline hyclate is known to cause edema over feet & ankles .. after prolonged use. The feeling of water droplets falling is due to pressure on periferal nerves supplying the skin of the part( periferal nuropathy. ) I don't know how many days have passed after stopping the doxycycline... mostly, if the edema is just a side effect of the drug.. it should disappear in 10 to 15 days ... with normal activities & sufficient water intake . * But if the edema persists for a longer time one should be aware of - kidney involvement / aggravation of kidney problem which may be already existing , In this context I would advise for checking urine ( routine & microscopic) & further evaluation & treatment as per need.Please consult your family doctor. - Health check up for other possible causes of edema feet like joint involvements/ high blood pressure/ weight gain because of diabetes or thyroid problem/ liver problem need to be investigated for as per need, after primary physical examination by a physician. In short persistent edema feet should be investigated to exclude any concerning cause & treated in time . I hope, the answer was both informative & useful to you. Any follow up query is welcome, Thank you.