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Does Methotrexate Interact With Clindamycin?

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Posted on Tue, 14 Mar 2017
Question: Can methotrexate taken last Saturday be a problem with clindamycin antibiotic taken the following Thursday. And should i stop the methotrexate until I finish the 10 day cycle of clindamycin?
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Answered by Dr. salah saad shoman (20 minutes later)
Brief Answer:
Yes discontinue methotrexate

Detailed Answer:
Dear XXXXXXX it is recommended that you discontinue methotrexate until you finish your antibiotic course. antibiotics decrease elimination of methotrexate and may increase its side effects. the dose of methotrexate you took on Saturday will not be affected by antibiotic dose on next Thursday . I hope I answered your question.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Nagamani Ng
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Answered by
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Dr. salah saad shoman

Internal Medicine Specialist

Practicing since :2004

Answered : 3150 Questions

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Does Methotrexate Interact With Clindamycin?

Brief Answer: Yes discontinue methotrexate Detailed Answer: Dear XXXXXXX it is recommended that you discontinue methotrexate until you finish your antibiotic course. antibiotics decrease elimination of methotrexate and may increase its side effects. the dose of methotrexate you took on Saturday will not be affected by antibiotic dose on next Thursday . I hope I answered your question.