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Is Estrogen-progestin Therapy Advisable When Having Fibroadenosis In Breast?
Question: Hi dr.
My friend is 47 years old . Postmenopause for 1 year ago. She has fibroadenosis in bilat breast .she did mammography and Ul once per year . Benign . No change. Now she like to be pregnant with egg donation . The prosedyre need estrogen replacememt 16 days before fertilization and througout pregnancy in high doses . Progynova tab 2mg ( estrogen ) , 5 tab x 4 and Estraderm 100 mg patches . Is this increase the chance of breast cancer in her situasjon or not?
regards
XXXX
My friend is 47 years old . Postmenopause for 1 year ago. She has fibroadenosis in bilat breast .she did mammography and Ul once per year . Benign . No change. Now she like to be pregnant with egg donation . The prosedyre need estrogen replacememt 16 days before fertilization and througout pregnancy in high doses . Progynova tab 2mg ( estrogen ) , 5 tab x 4 and Estraderm 100 mg patches . Is this increase the chance of breast cancer in her situasjon or not?
regards
XXXX
Brief Answer:
Fibroadenosis generally does not convert to cancer.
Detailed Answer:
Thanks for asking on HealthcareMagic.
Although Estrogen-progestin therapy (EPT) is linked to a higher risk of breast cancer, well-conducted studies have led many doctors to conclude that the risks of menopausal hormone therapy (MHT) often outweigh the benefits. The longer EPT is used, the higher the risk. The risk returns to that of a woman who never used EPT (the usual risk) within 3 years of stopping the hormones. To put the risk into numbers, if 10,000 women took EPT for a year, it would result in up to about 8 more cases of breast cancer per year than if they had not taken hormone therapy (HT).
However, let me mention that due to EPTalso that although the proability of development of breast cancer rises, fibroadenosis is unlikely to convert into breast cancer.
Regards
Fibroadenosis generally does not convert to cancer.
Detailed Answer:
Thanks for asking on HealthcareMagic.
Although Estrogen-progestin therapy (EPT) is linked to a higher risk of breast cancer, well-conducted studies have led many doctors to conclude that the risks of menopausal hormone therapy (MHT) often outweigh the benefits. The longer EPT is used, the higher the risk. The risk returns to that of a woman who never used EPT (the usual risk) within 3 years of stopping the hormones. To put the risk into numbers, if 10,000 women took EPT for a year, it would result in up to about 8 more cases of breast cancer per year than if they had not taken hormone therapy (HT).
However, let me mention that due to EPTalso that although the proability of development of breast cancer rises, fibroadenosis is unlikely to convert into breast cancer.
Regards
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Above answer was peer-reviewed by :
Dr. Neel Kudchadkar
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