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Is It Advisable To Undergo Triple Test During 15 Weeks Of Pregnancy?
Question: Hello Doctor
I am 13+ weeks pregnant(30 yr old), my doctor has asked me to go for Triple test in 15+ Weeks.
I had NT/NB Scan in 12th week and that was perfectly fine.
In my second abortion we have undergone for Chromosomal analysis of me and my husband and biopsy of "product of conception".
Autosomes of me and my husband was okay. But in product of conception Monosomy 17 Chromosomal was abnormal but report also stated that " No increased risk of chromosomal abnormality in future pregnancies provided that the parental karyotype are normal" and our karyotype was normal.
How necessary it is for me to go for triple test ?because NT NB scan and our karyotype was okay.
Can there be a risk ? because of last time Monosomy17 ?
I am little scared because first time my 3rd pregnancy is going well, and I wish no issues arise.
Could you please help ?
Thank you so much.
I am 13+ weeks pregnant(30 yr old), my doctor has asked me to go for Triple test in 15+ Weeks.
I had NT/NB Scan in 12th week and that was perfectly fine.
In my second abortion we have undergone for Chromosomal analysis of me and my husband and biopsy of "product of conception".
Autosomes of me and my husband was okay. But in product of conception Monosomy 17 Chromosomal was abnormal but report also stated that " No increased risk of chromosomal abnormality in future pregnancies provided that the parental karyotype are normal" and our karyotype was normal.
How necessary it is for me to go for triple test ?because NT NB scan and our karyotype was okay.
Can there be a risk ? because of last time Monosomy17 ?
I am little scared because first time my 3rd pregnancy is going well, and I wish no issues arise.
Could you please help ?
Thank you so much.
Brief Answer:
Please provide further info.
Detailed Answer:
Hello, Madam.
I understand your concern.
Before proceeding towards the answer, I would like to know some more facts.
Pertaining to the first pregnancy -1.I would like know the outcome.
2.Was karyotyping of the fetal tissue done then?
3.Was amniocentesis ever done in your case?
4.Was triple test done then?
Is there any family history of Down syndrome in either family?
I can guide with relevant answers once you post answers to these question in your follow up.
Thank you.
Please provide further info.
Detailed Answer:
Hello, Madam.
I understand your concern.
Before proceeding towards the answer, I would like to know some more facts.
Pertaining to the first pregnancy -1.I would like know the outcome.
2.Was karyotyping of the fetal tissue done then?
3.Was amniocentesis ever done in your case?
4.Was triple test done then?
Is there any family history of Down syndrome in either family?
I can guide with relevant answers once you post answers to these question in your follow up.
Thank you.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
At the time of my first abortion no tests were performed.
In 2nd abortion we have done cytogenetic profile of me, my husband, and product of conception and results i have described above.
No amniocentesis ever done
No triple test done before this would be the first time
No history of Down syndrome in both of our familes, we both have dozens of healthy uncle n aunts
I just need to need how much is the possibility of risk or there can be no risk ?
I would go for triple test....but isnt NT NB can enough see if things are gng fine ?
Please help
Thanks
In 2nd abortion we have done cytogenetic profile of me, my husband, and product of conception and results i have described above.
No amniocentesis ever done
No triple test done before this would be the first time
No history of Down syndrome in both of our familes, we both have dozens of healthy uncle n aunts
I just need to need how much is the possibility of risk or there can be no risk ?
I would go for triple test....but isnt NT NB can enough see if things are gng fine ?
Please help
Thanks
Brief Answer:
Go for the Triple test.Risk of Down baby is very low.
Detailed Answer:
Hello, Madam.
I apologize for my delayed response in view of my hectic schedule.
Based on your history given, the risk of having Down syndrome baby is extremely low in your case.
Between 65 to 85% of trisomic fetuses will have a large nuchal thickness.This leaves the measurement of nuchal transparency as a potentially useful 1st-trimester(<13 weeks) screening tool.But this is alone not sufficient.
For even greater accuracy of predicting risks, the outcome of the nuchal scan may be combined with the results of simultaneous maternal blood tests.
For 100% accuracy, I advise you to go for the Triple test as well as Ultrasound scan in the second trimester(13-24 weeks).
Normal Karyotype of parents alone will not rule out the possibility of having Down syndrome child.
Other factors for adjustment are maternal age and weight, insulin-dependent diabetes mellitus, multiple pregnancies, racial background, previous pregnancy with Down syndrome, and first or repeat test in a pregnancy.
Since you are negative for all these risk factors the probability for Down syndrome child is very low. The risk exists for women for >35yrs of age.
In case if Triple test screening is positive, it only suggests an increased risk for Down syndrome, and definitive testing with amniocentesis and chromosomal analysis(of the baby) is indicated.
To add a Note-On Monosomy 17 in previous abortion, I would like to tell you that it causes Koolen-de Vries syndrome-a disorder characterized by developmental delay and mild to moderate intellectual disability.
In most cases, this disorder is not inherited. The genetic change occurs most often as a random event during the formation of reproductive cells (eggs and sperm) or in early fetal development.
Hence, its probability recurrence in subsequent pregnancy cannot be quantified with accuracy.
Affected people typically have no history of the disorder in their family.
To conclude,
1. Go for the Triple test.
2. Risk, of Down syn extremely rare in current pregnancy.
3. Need for amniocentesis for detection of Monosomy 17(if any) in this pregnancy- is to be discussed with your doctor.
Post your further queries if any,
Thank you.
Go for the Triple test.Risk of Down baby is very low.
Detailed Answer:
Hello, Madam.
I apologize for my delayed response in view of my hectic schedule.
Based on your history given, the risk of having Down syndrome baby is extremely low in your case.
Between 65 to 85% of trisomic fetuses will have a large nuchal thickness.This leaves the measurement of nuchal transparency as a potentially useful 1st-trimester(<13 weeks) screening tool.But this is alone not sufficient.
For even greater accuracy of predicting risks, the outcome of the nuchal scan may be combined with the results of simultaneous maternal blood tests.
For 100% accuracy, I advise you to go for the Triple test as well as Ultrasound scan in the second trimester(13-24 weeks).
Normal Karyotype of parents alone will not rule out the possibility of having Down syndrome child.
Other factors for adjustment are maternal age and weight, insulin-dependent diabetes mellitus, multiple pregnancies, racial background, previous pregnancy with Down syndrome, and first or repeat test in a pregnancy.
Since you are negative for all these risk factors the probability for Down syndrome child is very low. The risk exists for women for >35yrs of age.
In case if Triple test screening is positive, it only suggests an increased risk for Down syndrome, and definitive testing with amniocentesis and chromosomal analysis(of the baby) is indicated.
To add a Note-On Monosomy 17 in previous abortion, I would like to tell you that it causes Koolen-de Vries syndrome-a disorder characterized by developmental delay and mild to moderate intellectual disability.
In most cases, this disorder is not inherited. The genetic change occurs most often as a random event during the formation of reproductive cells (eggs and sperm) or in early fetal development.
Hence, its probability recurrence in subsequent pregnancy cannot be quantified with accuracy.
Affected people typically have no history of the disorder in their family.
To conclude,
1. Go for the Triple test.
2. Risk, of Down syn extremely rare in current pregnancy.
3. Need for amniocentesis for detection of Monosomy 17(if any) in this pregnancy- is to be discussed with your doctor.
Post your further queries if any,
Thank you.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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