Brief Answer:
There exist safe profile antibiotics.

Detailed Answer:
Hello! Thank you for the question on HCM!
I understand your concern. Amiodaron can interact with many drugs and it is very important to choose the right drug which has minor or no interaction with it.
I would recommend cephalosporines like cefuroxime, ceftriaxone or penicillins like ampicilline, amoxycilline, etc.
Macrolide antibiotics like clarithromycin, erythromycin can increase Amiodaron blood levels, and risk for toxixity in special conditions..
Kinolons like levofloxacine,moxifloxacine are contraindicated as their combination with Amiodaron can cause QTs prolongation and can be life threatening.
When facing with concomitant use of Amiodaron and other drugs like for example antibiotics it is of crucial importance to have a full and continuous monitoring of liver and renal function tests coupled with continuous ECG monitoring and frequent blood electrolytes checks.
Nevertheless, there exists a broad range of antibiotics with a good safety profile, so don't worry. If a person is in a hospital settings and needs Amiodaron in the above conditions, doctors have all the necessary environment (including drugs, equipments like monitors, defibrillators, and also fast lab tests, highly specialised medical opinion) in order to perfectly manage such a common arrhythmia as atrial fibrillation is, even if they have to face with a pulmonary comorbidity.
If the patient experiences severe comorbidities, an it is of paramount importance to rapidly convert aFIb then an alternative and safe strategy is to perform electrical cardioversion of arrhythmia.
In that way we avoid uunwanted effects of drug combinations.
So to cut it short and clear for you I highly recommend you to relas and don't worry at all.
Just talk to the doctor for the best strategy in current patient condition.
Hope to have been helpful to you with the above information.
Fel free to contact me whenever you need.
Best regarding! Dr. Iliri

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Brief Answer:
avoid azithromycin with Amiodaron

Detailed Answer:
Hello! As I first explained to you Amiodarone used concomitantly with macrolides can highly increase the risk of QTs prolongation and life threatening arhythmia. So I would not recommend combination of Amiodarone and azytromycine which is a macrolide.
Tikosyn has the same serious interaction when combined with azithromycin. They both cause QTs prolongation.
Other alternatives should be tried.
Hope to have answered your questions.
Best wishes Dr Iliri

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