Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
Suggest Dosage For Solian
Question: Dear Dr. Sheppe,
My name is XXXXXXX i am sorry to ask again.
This friday i will start with Solian 50 mg instead of 100 mg (i take also Lexapro 15 mg, Keppra 1000mg and Klonopin 3 mg). I had my "fixation" (my eyes always looking to open windows of carts in the street) in 2008-2009, but it disappeared in 2009 changing from Lamictal to Keppra and i was then 4 weeks with Serlect (Sertindole), with bad effects, but with the elimination of this fixation. Maybe it helped to be four weeks without Solian and one week without any neuroleptic, even if Sertindole resolved the problem.
My question is: ¿Solian-Amisulpride can be now "blocking" the work of Lexapro and maybe other meds?¿It is possible to be for some time with Solian 50 mg and then to go back to Solian 100 mg, as it was done successfully in 2009, when i was three weeks with Serlect and one week without any neuroleptic?
Thanks beforehand for your attention, XXXXXXX
My name is XXXXXXX i am sorry to ask again.
This friday i will start with Solian 50 mg instead of 100 mg (i take also Lexapro 15 mg, Keppra 1000mg and Klonopin 3 mg). I had my "fixation" (my eyes always looking to open windows of carts in the street) in 2008-2009, but it disappeared in 2009 changing from Lamictal to Keppra and i was then 4 weeks with Serlect (Sertindole), with bad effects, but with the elimination of this fixation. Maybe it helped to be four weeks without Solian and one week without any neuroleptic, even if Sertindole resolved the problem.
My question is: ¿Solian-Amisulpride can be now "blocking" the work of Lexapro and maybe other meds?¿It is possible to be for some time with Solian 50 mg and then to go back to Solian 100 mg, as it was done successfully in 2009, when i was three weeks with Serlect and one week without any neuroleptic?
Thanks beforehand for your attention, XXXXXXX
Brief Answer:
Consultation
Detailed Answer:
Hello XXXXXXX very good to talk to you again. Never apologize for asking a question -- I want to do everything I can to help you, and I'm always happy to answer any question you have.
Lexapro works by blocking the serotonin transporter (SERT), whereas Solian has activity at D2, D3, and 5-HT7 receptors. The fact that the receptor targets are different points to the idea that Solian cannot be directly blocking the work of Lexapro. Indeed, because both drugs increase serotonin (on average), they actually complement each others' effects, and work well together synergistically.
I think that the solution to your problem is, in part, always having a neuroleptic on board. The difficulty is figuring out which one, and the dosage. I think you should definitely try Solian at 50mg and see how it goes. If necessary, it could always be raised to 100mg again, as you suggest. This is certainly a possibility and may be the best fit for you.
Let me know how it goes with the Solian 50mg. I hope you respond well to it. As always, reach out to me with any questions you have. I am always available to you.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Consultation
Detailed Answer:
Hello XXXXXXX very good to talk to you again. Never apologize for asking a question -- I want to do everything I can to help you, and I'm always happy to answer any question you have.
Lexapro works by blocking the serotonin transporter (SERT), whereas Solian has activity at D2, D3, and 5-HT7 receptors. The fact that the receptor targets are different points to the idea that Solian cannot be directly blocking the work of Lexapro. Indeed, because both drugs increase serotonin (on average), they actually complement each others' effects, and work well together synergistically.
I think that the solution to your problem is, in part, always having a neuroleptic on board. The difficulty is figuring out which one, and the dosage. I think you should definitely try Solian at 50mg and see how it goes. If necessary, it could always be raised to 100mg again, as you suggest. This is certainly a possibility and may be the best fit for you.
Let me know how it goes with the Solian 50mg. I hope you respond well to it. As always, reach out to me with any questions you have. I am always available to you.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Above answer was peer-reviewed by :
Dr. Yogesh D
Dear Dr. Sheppe,
Thanks alot for your clear answer. I have just another question for the while: how long it takes to Lexapro to reach a steady plasma concentration or stability with full effects? Until now and waiting for the new dose of Solian, some days i feel almost without my fixation and some days this fixation appears again, it changes a lot. I feel something is still unstable.
Thanks again, XXXXXXX
Thanks alot for your clear answer. I have just another question for the while: how long it takes to Lexapro to reach a steady plasma concentration or stability with full effects? Until now and waiting for the new dose of Solian, some days i feel almost without my fixation and some days this fixation appears again, it changes a lot. I feel something is still unstable.
Thanks again, XXXXXXX
Brief Answer:
Followup
Detailed Answer:
Of course, my pleasure.
Lexapro, like most drugs, requires about 5 half-lives to reach steady-state concentration in the plasma. The half-life of Lexapro is about a day. So, Lexapro reaches steady-state in about 5 days. The instability you're noticing may be improved once the Solian is stably at its lower dose.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Followup
Detailed Answer:
Of course, my pleasure.
Lexapro, like most drugs, requires about 5 half-lives to reach steady-state concentration in the plasma. The half-life of Lexapro is about a day. So, Lexapro reaches steady-state in about 5 days. The instability you're noticing may be improved once the Solian is stably at its lower dose.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Sonia Raina
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
